Klinefelter’s syndrome (KS) is a condition that results in boys who have an extra X chromosome in most of their cells. The first documented case was in 1942 and it is the second most common extra chromosome condition, occurring in about 1 out of every 500-1,000 newborn males. Women who have pregnancies after age 35 are slightly more likely to have baby boys with this syndrome. Affected males are often referred to as XXYs or 47s as the average human has 46 chromosomes while those with Klinefelter’s have 47.