Our decision to discuss animal research arose from several questions that we think are important to consider, as scientists who have used, or might use, animal models at some point in our career. First, we wondered who is in charge of the regulation of lab animals. Who is keeping track of the numbers, and who monitors the treatment of these lab animals? Secondly, we wanted to investigate the written legal restrictions on use of animals in scientific research. Where is the line drawn between what is acceptable to do to an animal and what isn’t?