Each of us has encountered a “loud” shirt or “warm” colors, however, for most individuals these terms are metaphors and not actual physical experiences. Those living with the neurological condition synesthesia, in fact, do encounter this blending of senses on a regular basis. Senses like hearing and vision, or touch and taste become combined in the synesthete’s brain rather than remaining separate as in the majority of the population. The study of synesthesia dates as far back as 1880 with the work of Francis Galton in the journal Nature. However, due to the stigma that synesthesia is the product of the imagination, memories from childhood, or drug experiences, little interest was expressed in the subject until recently.1 The condition is very subjective in nature, causing most of the data obtained to be qualitative rather than quantitative. This fact makes it difficult to have any conclusive physical evidence about synesthesia. Scientists do not have a clear answer as to what causes synesthesia or even as to what is occurring within the brain of a synesthete. Although many theories have been purposed, the many complexities of this fascinating condition are likely to keep researchers puzzled for years to come.