I think its actually an open question whether "hopelessness, anxiety, and suicidal thoughts" are an intrinsic characteristic of the "brain state" or something that results from how people with that brain state are treated by those around them. That isn't to say I wouldn't encourage people with those feelings to seek medical help, but I do think its another case where care-givers should at least think about whether what is needed is changes in individuals or changes in culture.