Alumnae Contact Information
Department of Pharmacology & Molecular Biophysics Graduate Program
University of Texas Southwestern Medical Center at Dallas (UT Southwestern)
6001 Forest Park, ND8.120C, Dallas, TX 75390-9041
E-mail yuhmin.chook@utsouthwestern.edu
http://www.utsouthwestern.edu/findfac/professional/0,2356,53719,00.html
Only two classes of NLS and one class of NES are currently known. The short lysine-rich classical-NLS was discovered in the early 1980s and is recognized by Kapα/Kapβ1. More recently, our lab has defined a class of significantly larger and more diverse NLS termed the PY-NLS, which is recognized by Kapβ2. On the other hand, the only known NES is the leucine-rich NES, which is recognized by export-Kapβ CRM1. We have recently solved the first structure of a CRM1-Leucine rich NES complex, which explains recognition of this general signal, its inhibition by antibiotic Leptomycin B and mechanisms of export complex assembly in the nucleus as well as disassembly in the cytoplasm....
Recent Publications:
1. Lee, B. J., Cansizoglu, A. E., Süel, K. E., Louis, T. H., Zhang, Z. and Chook, Y.
M. (2006) Rules for nuclear localization sequence recognition by Karyopherinβ2.
Cell, 126:543-558.
2. Cansizoglu, A. E., Lee, B. J., Zhang, Z. C., Fontoura, B. M. A. and Chook, Y. M.
(2007) Structure-based design of a pathway-specific nuclear import inhibitor. Nat.
Struc. & Mol. Biol., 14(5):452-454.
3. Cansizoglu, A. E. and Chook, Y. M. (2007) Conformational heterogeneity of
Karyopherinβ2 is segmental. Structure, 15(11):1431-1441.
Christina Cuomo, Ph.D.
Research Scientist
Broad Institute of MIT and Harvard
7 Cambridge Center
Cambridge, MA 02142
phone: (617) 452-4735
fax: (617) 324-4987
http://www.broad.mit.edu/genome_bio/bios/bio-cuomo.htmlHistoplasma capsulatum is thought to be the most common cause of fungal respiratory infections in the world. This organism is a primary pathogen capable of causing disease in healthy hosts as well as immunocompromised individuals. Whereas most infections experienced by healthy hosts are mild, 10% of cases of H. capsulatum infection result in life-threatening complications, such as inflammation of the pericardium and fibrosis of major blood vessels. We have recently sequenced the genomes from histoplasma strains from the two major North American clades, and two strains from the African clade with different disease manifestations. A summer project would be to conduct comparative genomic analyses between these strains, to identify polymorphisms and larger differences. This will identify genetic traits that correlate with different strains, and identify rapidly evolving regions of the genome which could contribute to pathogenesis. This is a computational biology/bioinformatics project, requiring some prior familiarity with
bioinformatic tools and some programming experience, such as with perl
or python.
S.E. Roian Egnor ('90), Fellow
HHMI - Janelia Farm Research Campus, 19700 Helix Drive,Ashburn, VA 20147
egnorr@janelia.hhmi.org
http://www.hhmi.org/research/fellows/egnor.html http://www.hhmi.org/janelia/undergrad.html.
Dr. Andrea J. Fascetti, VMD PhD (’87), Diplomate ACVIM and ACVN, Associate Professor Nutrition
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis
Dr. Fascetti has a 40% clinical appointment in the Veterinary Medical Teaching Hospital on the Nutrition Support Service and is board certified in both veterinary nutrition and internal medicine... research focuses on comparative nutrition with an emphasis on the nutrition of carnivores, in particular cats. A large portion of research arises from clinical problems...current research interests are energy expenditure, trace mineral and amino acid metabolism in dogs and cats, improvement of pet foods and carnivore nutrition.
Some examples of recent publications include:
2007 Maggs, DJ, Sykes JE, Clarke HE, Yoo SH, Kass PH, Lappin MR, Rogers QR, Waldron ME, Fascetti AJ. Effects of dietary lysine supplementation in cats with enzootic upper respiratory disease. Journal of Feline Medicine and Surgery, 92(2): 97-108.
2007 Weeth LP, Fascetti AJ, Kass PH, Suter SE, Santos AM, Delaney SJ. Prevalence of obese dogs in a population of dogs with cancer. Am J Vet Res, 68(4): 389-98.
2008 Laflamme DP, Abood SK, Fascetti AJ, Fleeman LM, Freeman LM, Michel KE, Bauer C, Kemp BL, Doren JR, Willoughby KN. Pet feeding practices of dog and cat owners in the United States and Australia. J Am Vet Med Assoc, 232(5): 687-94.
email: chann1@jhmi.edu
phone: 410-502-0678 fax: 410-502-0677
Available Summer 2010
Broad Center for Regenerative Medicine & Stem Cell Research, Keck School of Medicine
University of Southern California
NRT-4505, MC9601
1450 Biggy Street
Los Angeles, CA 90033
tel: 323-442-7855/fax: 323-442-7899
fmariani@usc.edu
http://stemcell.usc.edu/francesca-mariani.html
Medical College of Wisconsin, 8701 Watertown Plank Rd.
Milwaukee, WI 53226
Phone: 414-456-4244 (office)/4236 (lab) Fax: 414-266-3676
Email: nsalzman@mcw.edu Salzman
Halas Group Webpage: http://www.ece.rice.edu/~halas/
LaNP webpage : http://lanp.rice.edu/
Associate Professor of Chemistry, University of Michigan, Department of Chemistry
930 N University Ave, Ann Arbor, MI 48109
amapp@umich.edu
Phone: 734.615.6862/Fax: 734.615.8553
Veronika Szalai ('88)
Department of Chemistry & Biochemistry, University of Maryland
Baltimore County, Baltimore, MD 21250
410-455-1576
vszalai@umbc.edu http://umbc.edu/chem/general/user/vszalai
COMPUTER SCIENCE
Dr. Kathleen Kerr('92), Associate Professor
University of Washington, Department of Biostatistics, Box 357232
Seattle, Washington 98195-7232
206-543-1044 (phone) 206-543-3286 (fax)
katiek@u.washington.edu
http://depts.washington.edu/biostat/
Dr. Jacqueline A. MacDonald (’86), Assistant Professor
Department of Environmental Sciences and Engineering, School of Public Health, 162B Rosenau Hall
University of North Carolina, Chapel Hill, Chapel Hill, NC 27599
Phone: 919-966-7892
E-mail: jackie.macdonald@unc.edu
....research is entirely based on computer modeling.
MATHEMATICS
My current work is in the area of so-called combinatorial and additive number theory.
Rutgers University, 152 Frelinghuysen Road, Piscataway NJ 08854-8020
gbc@rci.rutgers.edu
www.rci.rutgers.edu/~gbc or mdmlab.rutgers.edu
Psychology of Decision Making....How does human decision making deviate from rational models? Using questionnaire studies with hypothetical scenarios and laboratory studies of interactive tasks we explore the psychological processes underlying decision making in domains such as statistical reasoning, saving behavior, electricity use, and vaccination choices.
Associate Professor of Psychology and Linguistics
University of Pittsburgh, 3415 Sennott Square, 210 S. Bouquet St., Pittsburgh, PA 15260
Phone: 412.624.6160/ Fax: 412.624.4428
Email: jiverson@pitt.edu
http://www.pitt.edu/~icl
Briefly, our current research focus on characterizing the early development of infants who have an older sibling diagnosed with an autism spectrum disorder (ASD) and are thus at heightened biological risk for ASD. Because current recurrence risks indicate that these infants have an 18-20% chance of eventually receiving an ASD diagnosis, we are also seeking to identify early behavioral indicators of ASD. ASD cannot be reliably diagnosed before age 2, yet many parents of children with ASD report having had concerns about their child's development as early as 6 months of age. Early identification is prerequisite to early intervention, which generally leads to better outcomes. In addition, very little is known about when and how symptoms of ASD manifest in early infancy, so we also hope to further our understanding of the development of infants eventually diagnosed with ASD and identify potential mechanisms that may underlie the emergence of early ASD symptoms.
Assistant Professor
Department of Psychiatry, University of Pennsylvania
215-662-2815
My research focuses on the treatment of depression during pregnancy. I am investigating the safety and feasibility of the use a novel neuromodulator, transcranial magnetic stimulation, in this special population. The work includes direct patient contact, learning about this novel treatment, understanding study design and data analysis.
2500 University Drive N.W., Calgary, Alberta T2N 1N4 Canada
Office: (403) 220-7085 Fax: (403) 282-8249 Lab: (403) 210-9438
http://psych.ucalgary.ca/eatinglab/
The project I have in mind .... involves recruiting people with and without eating and substance use disorders from the community and and completing clinical interviews with them.
